Cytogenetic study of the continuous RH cell line and its clones with a different susceptibility to measles virus

A comparative karyological study was carried out on the RH continuous line of human embryo kidney cells and its 3 clones differing in their sensitivity to the cytopathic effect (CPE) of vaccine measles virus (L-16 strain). The clonal variants studied were shown to have different karyotypes and their sensitivities to be genetically determined. There was a correlation between the rate of appearance and the pattern of the CPE and the percentage of cells in which a set of 33 chromosomes and a high level of polyploidy were combined.