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Biodegradable polyesters containing ibuprofen and naproxen as pendant groups.

Roselin Rosario-Meléndez1, Weiling Yu, Kathryn E Uhrich

  • 1Department of Chemistry and Chemical Biologyand ‡Department of Biomedical Engineering, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.

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New biodegradable polyesters offer controlled release of nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen. These biocompatible materials show no cytotoxicity and preserve drug bioactivity after degradation.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Controlled release of nonsteroidal anti-inflammatory drugs (NSAIDs) can improve treatment efficacy for inflammatory diseases.
  • Continuous NSAID use can lead to significant side effects.
  • Developing novel drug delivery systems is crucial for safer and more effective therapies.

Purpose of the Study:

  • To synthesize and characterize novel biodegradable polyesters for controlled NSAID release.
  • To evaluate the in vitro drug release kinetics and cytotoxicity of the developed biomaterials.
  • To confirm the preservation of drug chemical structure and bioactivity after polymer degradation.

Main Methods:

  • Synthesis of biodegradable polyesters using tartaric acid, 1,8-octanediol, and NSAIDs (ibuprofen or naproxen) as pendant groups.
  • Catalysis using tin(II) 2-ethylhexanoate at 130 °C.
  • Characterization of polymer structures and physicochemical properties.
  • In vitro drug release studies and cytotoxicity assays using mouse fibroblasts.

Main Results:

  • Successfully synthesized novel biodegradable polyesters containing ibuprofen or naproxen.
  • Demonstrated controlled in vitro drug release without burst release, outperforming other polymer encapsulation methods.
  • Established that the biomaterials are non-cytotoxic to mouse fibroblasts at concentrations up to 0.10 mg/mL.
  • Confirmed that the released drugs retain their chemical structure, indicating preserved bioactivity.

Conclusions:

  • Novel biodegradable polyesters offer a promising platform for controlled release of NSAIDs.
  • These biocompatible materials provide a safer alternative for managing inflammatory diseases by minimizing side effects.
  • The preserved bioactivity of released drugs suggests therapeutic potential for these advanced biomaterials.