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Related Experiment Video

Updated: May 8, 2026

An Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme

An Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme

Published on: January 20, 2013

Split mesencephalon: diplomyelia of the basicranium.

Bodiabaduge A P Jayasekera¹, Erlick A C Pereira, Shailendra Magdum

¹Department of Paediatric Neurosurgery, Oxford Children's Hospital and The West Wing, John Radcliffe Hospital , Oxford , UK.

British Journal of Neurosurgery

|August 21, 2013

Summary

A rare congenital brain abnormality, congenitally split mesencephalon, was observed in a child with hydrocephalus. This finding suggests a potential shared developmental origin with split cord malformations.

Keywords:

anomaly cyst diplomyelia mesencephalon posterior fossa split cord malformation

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Area of Science:

Neuroscience
Developmental Biology
Pediatric Neurology

Background:

Congenital brain malformations represent a significant area of study in pediatric neurology.
Split cord malformations (SCM) are a known group of congenital anomalies affecting the spinal cord.
Understanding the developmental origins of brain and spinal cord malformations is crucial for diagnosis and treatment.

Observation:

A unique case of congenitally split mesencephalon was identified in a 3-year-old patient.
The patient also presented with hydrocephalus, a condition characterized by excess cerebrospinal fluid in the brain.
This observation is particularly noteworthy due to its rarity and potential implications for understanding brain development.

Findings:

The reported case of split mesencephalon in a pediatric patient is novel.
The study speculates a shared ontogenetic mechanism between congenitally split mesencephalon and split cord malformations (SCM).
This case expands the spectrum of known SCM-related anomalies, linking them to more caudal brainstem involvement.

Implications:

This finding may lead to a revised understanding of the embryological development of the central nervous system.
Further research into shared developmental pathways could uncover new diagnostic markers or therapeutic targets for SCM and related brain malformations.
The case highlights the importance of considering brain anomalies in the differential diagnosis of SCM and vice versa.