Primary cutaneous B-cell lymphomas: part I. Clinical features, diagnosis, and classification

Area of Science:

• Dermatology
• Oncology
• Hematopathology

Background:

• Primary cutaneous B-cell lymphomas (PCBCLs) are extranodal non-Hodgkin lymphomas originating in the skin.
• The skin is the second most common extranodal site for non-Hodgkin lymphomas.
• PCBCLs share histological similarities with nodal lymphomas, potentially causing diagnostic and therapeutic confusion.

Purpose of the Study:

• To summarize the clinical, pathological, and diagnostic features of three main PCBCL subtypes.
• To outline appropriate evaluation and staging procedures for these entities.
• To aid in differentiating PCBCLs from nodal lymphomas and guiding treatment decisions.

Main Methods:

• Review of clinical presentations of PCBCLs.
• Analysis of pathological and diagnostic criteria for PCBCL subtypes.
• Summary of recommended staging and evaluation protocols.

Main Results:

• Detailed description of primary cutaneous follicle center lymphoma, primary cutaneous marginal zone lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg-type.
• Emphasis on distinguishing features and diagnostic challenges for each subtype.
• Guidance on staging to exclude extracutaneous disease.

Conclusions:

• Accurate diagnosis and staging are crucial for managing PCBCLs.
• Understanding the distinct features of each PCBCL subtype is essential for appropriate therapeutic strategies.
• This review provides a framework for the evaluation and management of primary cutaneous B-cell lymphomas.