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Early parenteral lipids and growth velocity in extremely-low-birth-weight infants
Céline Julie Fischer1, Delphine Maucort-Boulch2, Christine Murielle Essomo Megnier-Mbo3
1Service de Réanimation Néonatale et Néonatologie, Hôpital Femme Mère Enfants, Hospices Civils de Lyon, Bron, France; Service de Néonatologie, Département Médico-Chirurgical de Pédiatrie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Switzerland.
Insights
Early parenteral lipids significantly improve weight gain and head circumference growth in extremely-low-birth-weight infants. This suggests early lipid administration enhances postnatal growth and nutritional support for preterm neonates.
Area of Science:
- Neonatology
- Pediatric Nutrition
- Growth and Development
Background:
- Postnatal growth in extremely-low-birth-weight (ELBW) infants is critical.
- The role of early parenteral lipids in optimizing growth velocity remains incompletely understood.
Purpose of the Study:
- To investigate the impact of early parenteral lipid administration on the growth velocity of ELBW infants.
- To assess the association between cumulative parenteral lipid intake and growth parameters.
Main Methods:
- Retrospective cohort study of 121 ELBW infants.
- Analysis of associations between parenteral lipid intake (cumulative and delayed introduction) and growth velocities (weight, head circumference, length) up to 28 days and 36 weeks corrected age.
- Uni- and multivariate linear regression analyses were employed.
Main Results:
- Positive associations were observed between cumulative early parenteral lipid intake and weight gain (up to 28 days and 36 weeks corrected age) and head circumference growth (up to 28 days).
- Delayed introduction of parenteral lipids correlated negatively with weight gain up to 28 days.
- Multivariate analyses confirmed the independence of these associations from other key neonatal factors.
Conclusions:
- Early administration of parenteral lipids in the first week is positively associated with improved weight gain in ELBW infants.
- Parenteral lipids are crucial for enhancing early nutritional support and promoting optimal growth in preterm neonates.
Background & Aims:
Whether early parenteral lipids improve postnatal growth of preterm neonates remains unclear. We aimed to assess the effects of parenteral lipids on growth velocity in extremely-low-birth-weight infants.
Methods:
This retrospective cohort study included 121 extremely-low-birth-weight infants. The associations between parenteral lipids (cumulative intakes during the first week and delays in their introduction) and growth velocities (weight, head circumference and length) up to 28 days of life and to 36 weeks of corrected age were analysed using uni- and multivariate linear regression.
Results:
Univariate analyses showed a significant positive association between the cumulative intakes of parenteral lipids during the first week and i) weight gain up to day 28; ii) weight gain up to 36 weeks of corrected age; iii) head circumference growth up to day 28. There was a negative correlation between the delay in parenteral lipid introduction and weight gain up to day 28. In multivariate analyses, the association between the cumulative intakes of parenteral lipids and weight gain up to 28 days was independent of gestational age at birth, birth weight, sex, smallness for gestational age, and enteral intakes (regression coefficient: 0.19; 95% CI: 0.01-0.38) and, up to 36 weeks, independent of gestational age, birth weight, sex, smallness for gestational age and parenteral glucose and amino acids (0.16; 95% CI: 0.04-0.27).
Conclusions:
Parenteral lipids during the first week were positively associated with weight gain in extremely-low-birth-weight infants and could improve early nutritional support of preterm neonates.
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