Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Clocks and Seasonal Responses

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Generation Time

Generation Time

Bacterial generation time, the period required for a bacterial population to double during its exponential growth phase, serves as a critical measure of microbial growth dynamics under optimal conditions. This parameter varies significantly across bacterial species and can be influenced by factors such as temperature, pH, and the availability of nutrients. For example, Escherichia coli can achieve a generation time of approximately 20 minutes, while Mycobacterium tuberculosis exhibits a much...

Life Histories

Life Histories

Wald-Wolfowitz Runs Test II

Wald-Wolfowitz Runs Test II

The Wald-Wolfowitz runs test, commonly referred to as the runs test, is a nonparametric test used to assess the randomness of ordered data. The test evaluates the number of runs, which are consecutive sequences of similar elements within the data. If the number of runs is significantly higher or lower than expected, the data is considered non-random, indicating a detectable pattern or structure.
For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and 0s. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Collagen nanofiber reinforced alginate hydrogel tube microbioreactors for cell culture.

Frontiers in bioengineering and biotechnology·2026

Same author

Towards mRNA therapeutics 2.0.

Nature reviews. Drug discovery·2026

Same author

Collagen hydrogel tube microbioreactors for cell and tissue manufacturing.

Biofabrication·2025

Same author

Pluripotent stem cell-derived extracellular vesicles for systemic immune modulation in diabetes therapy.

Research square·2025

Same author

Collagen Nanofiber Reinforced Alginate Hydrogel Tube Microbioreactors for Cell Culture.

bioRxiv : the preprint server for biology·2025

Same author

Gas Vesicle-Expressing Human Pluripotent Stem Cells Enable Multimodal Ultrasound and Optical Coherence Tomographic Imaging.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: May 8, 2026

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Published on: November 11, 2011

The years of the monkey.

Xiaojun Lian¹, Kenneth R Chien

¹Departments of Cell and Molecular Biology and Medicine, Karolinska Institutet, Stockholm, Sweden.

|August 21, 2013

Summary

This summary is machine-generated.

Mammals' diploid nature hinders gene function studies. Researchers successfully derived monkey haploid embryonic stem cells, creating a platform for studying gene function and recessive phenotypes.

More Related Videos

The Gateway to the Brain: Dissecting the Primate Eye

The Gateway to the Brain: Dissecting the Primate Eye

Published on: May 27, 2009

Dissecting the Non-human Primate Brain in Stereotaxic Space

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

Related Experiment Videos

Last Updated: May 8, 2026

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Published on: November 11, 2011

The Gateway to the Brain: Dissecting the Primate Eye

The Gateway to the Brain: Dissecting the Primate Eye

Published on: May 27, 2009

Dissecting the Non-human Primate Brain in Stereotaxic Space

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

Area of Science:

Genetics
Developmental Biology
Stem Cell Biology

Background:

Mammals are typically diploid, making it challenging to study gene function due to genetic redundancy.
Understanding the roles of both coding and non-coding genes is crucial for advancing genomic research.

Purpose of the Study:

To establish a platform for efficient gene function studies in mammals.
To enable reverse genetic screening for recessive phenotypes in a primate model.

Main Methods:

Derivation of haploid embryonic stem cells from monkey parthenotes.
Utilizing these cells for gene function analysis and genetic screening.

Main Results:

Successful derivation of monkey haploid embryonic stem cells.
Demonstration of the utility of these cells for studying gene function.
Establishment of a method for reverse genetic screening of recessive phenotypes.

Conclusions:

Monkey haploid embryonic stem cells offer a powerful tool for mammalian gene function research.
This breakthrough facilitates the study of recessive genetic traits and diseases in primates.