Related Experiment Video
Updated: May 8, 2026

14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
Published on: January 27, 2010
Anesthetic considerations for high order cesarean sections: a prospective cohort study
Archives of Gynecology and Obstetrics
|August 21, 2013
Summary
High order repeat cesarean sections (HOR-C/S) increase surgery duration and blood transfusion needs but do not raise anesthesia conversion rates. HOR-C/S is not an absolute contraindication for regional anesthesia if hemorrhage causes are excluded.
Area of Science:
- Obstetrics and Gynecology
- Surgical Outcomes
- Maternal Health
Background:
- Previous retrospective studies indicated low complication rates for high order repeat cesarean sections (HOR-C/S).
- This study prospectively compares complication incidence in patients undergoing four or more cesarean sections versus three or fewer.
Purpose of the Study:
- To compare the incidence of perioperative complications between high order repeat cesarean sections (HOR-C/S) and lower order cesarean sections.
- To evaluate anesthesia conversion rates, surgical duration, and blood loss in HOR-C/S.
Main Methods:
- Prospective, observational cohort study.
- Inclusion of parturients undergoing cesarean section (C/S) at a single tertiary care hospital over one year.
- Comparison of HOR-C/S (four or more C/S) with a control group (three or fewer C/S).
Main Results:
- 129 HOR-C/S cases were compared to 702 controls.
- Prolonged surgery incidence was significantly higher in the HOR-C/S group (RR = 3.6).
- Intraoperative blood transfusion incidence was also higher in the HOR-C/S group (RR = 3.4).
- Conversion from regional to general anesthesia rates were similar between groups.
Conclusions:
- Patients undergoing HOR-C/S face increased risks of prolonged surgery and requiring blood transfusions.
- Regional anesthesia remains a viable option for HOR-C/S when severe hemorrhage causes are ruled out.
- HOR-C/S is not an absolute contraindication for regional anesthesia in this patient population.
Related Concept Videos
Local Anesthetics: Clinical Application as Epidural Anesthesia
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
General Anesthesia: Overview
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Local Anesthetics: Clinical Application as Spinal Anesthesia
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Inhalational Anesthetics: Overview
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Stages of General Anesthesia
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...

