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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

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Epigenetic developmental programs and adipogenesis: implications for psychotropic induced obesity.

Kayla Chase¹, Rajiv P Sharma²

¹The Psychiatric Institute; University of Illinois at Chicago; Chicago, IL USA.

|August 21, 2013

Summary

Psychotropic medications can increase patient fat mass by affecting fat cell production and lipid accumulation. Epigenetic mechanisms, influenced by these drugs, may be a common pathway for these metabolic changes.

Keywords:

epigenetics histone methylation obesity psychotropics schizophrenia

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Area of Science:

Biochemistry
Pharmacology
Genetics

Background:

Psychotropic agents are known to increase fat mass in psychiatric patients.
Fat mass is determined by adipogenesis (new fat cell production) and lipid accumulation.
Epigenetic programs play a crucial role in cell differentiation, including adipogenesis.

Purpose of the Study:

To explore the role of epigenetic mechanisms in psychotropic-induced weight gain.
To investigate how psychotropic drugs might influence adipogenesis and energy metabolism via epigenetic pathways.
To highlight potential therapeutic targets for managing metabolic side effects of psychotropic medications.

Main Methods:

Review of current literature on psychotropic pharmacology and epigenetics.
Analysis of the link between G protein-coupled receptor signaling and epigenetic enzymes.
Examination of genetic models demonstrating epigenetic effects on energy metabolism.

Main Results:

Psychotropic medications may share common epigenetic pathways to increase adipogenesis or reduce energy metabolism.
Surface receptor activity modulated by psychotropics can directly impact epigenetic regulatory enzymes.
Histone demethylase inhibition, as seen with tranylcypromine, shows therapeutic potential for metabolic issues.

Conclusions:

Epigenetic modifications are a likely mechanism underlying psychotropic-induced metabolic changes.
Targeting epigenetic pathways offers a novel therapeutic strategy for managing weight gain in patients on psychotropic drugs.
Further research into specific epigenetic effectors could lead to improved treatment outcomes.