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Related Experiment Videos

Opponent strain effect on eliciting attacks in NZB mice: physiological correlates.

M H Francois1, M Nosten-Bertrand, P L Roubertoux

  • 1Génétique, Neurogénétique et Comportement, URA 1294 CNRS, UER Biomédicale Université Paris V René Descartes, France.

Physiology & Behavior
|June 1, 1990
PubMed
Summary

Male mouse strain characteristics influence aggression. BALB/c mice elicit more attacks than C57BL/6 mice, linked to testosterone sensitivity and secretions.

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Area of Science:

  • Behavioral Neuroscience
  • Animal Behavior
  • Genetics

Background:

  • Opponent characteristics can modulate aggressive behavior in male mice.
  • Previous studies suggest strain differences in agonistic encounters.

Purpose of the Study:

  • To investigate strain-dependent differences in eliciting aggressive behavior in male mice.
  • To explore the role of testosterone and secretions in these behavioral differences.

Main Methods:

  • Agonistic encounters between NZB males and BALB/c or C57BL/6 opponents.
  • Measurement of plasma testosterone concentrations.
  • Hormonal response of seminal vesicles and submandibular glands to testosterone propionate (TP) injections in castrated males.
  • Quantification of marking secretions.

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Main Results:

  • BALB/c opponents elicited more frequent, earlier, and intensive attacks compared to C57BL/6 opponents.
  • BALB/c males had higher plasma testosterone levels and showed greater seminal vesicle growth in response to TP.
  • Submandibular glands reacted to TP only in BALB/c males at higher doses.
  • BALB/c males produced more marking secretions.

Conclusions:

  • Testosterone sensitivity and increased secretion production in BALB/c males are associated with a higher probability of eliciting attacks.
  • Strain-specific genetic factors likely underlie these observed differences in behavior and physiology.