Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Nuclear Protein Sorting01:34

Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
Nuclear Export01:42

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing an avian influenza vaccine using a novel Bacterial Enzymatic Combinatorial Chemistry (BECC) TLR4 adjuvant.

mSphere·2026
Same author

Variable transmission efficiency of mammalian origin HPAI D1.1 H5N1 strains in ferrets.

bioRxiv : the preprint server for biology·2026
Same author

Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses.

Cell host & microbe·2026
Same author

Fatal human H3N8 influenza virus has a moderate pandemic risk.

PLoS pathogens·2026
Same author

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections.

bioRxiv : the preprint server for biology·2026
Same author

Erratum for Rockey et al., "Seasonal influenza viruses decay more rapidly at intermediate humidity in droplets containing saliva compared to respiratory mucus".

Applied and environmental microbiology·2026

Related Experiment Video

Updated: May 8, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

Viral subversion of the nuclear pore complex.

Valerie Le Sage1, Andrew J Mouland

  • 1Lady Davis Institute at the Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada. valerie.lesage@mail.mcgill.ca

Viruses
|August 21, 2013
PubMed
Summary
This summary is machine-generated.

Viruses hijack the nuclear pore complex (NPC), a gatekeeper between the nucleus and cytoplasm, to facilitate their replication. This review details viral strategies for manipulating the NPC and nucleoporins to promote infection and evade host defenses.

Related Experiment Videos

Last Updated: May 8, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

Area of Science:

  • Cell Biology
  • Virology
  • Molecular Biology

Background:

  • The nuclear pore complex (NPC) regulates molecular transport between the nucleus and cytoplasm.
  • Viruses have evolved mechanisms to exploit the NPC for their life cycle.
  • Understanding these interactions is crucial for developing antiviral strategies.

Purpose of the Study:

  • To review the diverse strategies employed by viral pathogens to hijack the NPC.
  • To identify specific nucleoporins involved in viral nuclear import/export.
  • To explore how viruses manipulate the NPC to promote replication and overcome host defenses.

Main Methods:

  • Literature review of viral-host interactions at the NPC.
  • Analysis of studies detailing viral protein and genome trafficking.
  • Examination of nucleoporin involvement in viral life cycles.

Main Results:

  • Viruses utilize various strategies to interact with and manipulate NPC components.
  • Specific nucleoporins are targeted by different viruses to facilitate nuclear transport.
  • Viral hijacking of the NPC aids in replication and subversion of host immunity.

Conclusions:

  • Viral exploitation of the NPC is a common and critical aspect of numerous infections.
  • Targeting NPC-host interactions presents a potential avenue for antiviral therapies.
  • Further research into nucleoporin-virus interactions can reveal novel therapeutic targets.