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Updated: May 8, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Green synthesis of α-aminophosphonate derivatives on a solid supported TiO2 -SiO2 catalyst and their anticancer
Radha Rani Chinthaparthi1, Ira Bhatnagar, Chandra Sekhar Reddy Gangireddy
1Department of Chemistry, Sri Venkateswara University, Tirupati, Andra Pradesh, India.
Abstract:
Syntheses of a new series of biologically potent α-aminophosphonates were accomplished by one-pot Kabachnik-Fields reaction using TiO2-SiO2 as solid supported catalyst under microwave irradiation conditions. The chemical structures of all the newly synthesized compounds were confirmed by analytical and spectral (IR, 1H, 13C, 31P NMR, and mass) data. Their anticancer nature was evaluated by screening the in vitro activity on two human cancer cell lines, HeLa and SK-BR-3. Compounds 4i and 4o showed the best activity on these cancer cells even though the majority of the compounds, and particularly 4l and 4p, have good cytotoxic activity against them.
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