Related Experiment Video

Updated: May 8, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Malignant mesothelioma: development to therapy

Joyce K Thompson1, Catherine M Westbom, Arti Shukla

  • 1Pathology Department, University of Vermont, College of Medicine, Burlington, Vermont.

Journal of Cellular Biochemistry
|August 21, 2013
PubMed

Insights

Malignant mesothelioma (MM) remains a threat due to asbestos exposure, even with reduced use. Continued research into its developmental mechanisms and therapies is crucial for early diagnosis and treatment of this aggressive cancer.

Area of Science:

  • Oncology
  • Environmental Health

Background:

  • Malignant mesothelioma (MM) is an aggressive cancer linked to asbestos exposure.
  • Despite reduced asbestos use, environmental asbestos release ensures continued risk.
  • The long latency period of MM necessitates ongoing research even if asbestos is eliminated today.

Purpose of the Study:

  • To review the developmental mechanisms of malignant mesothelioma.
  • To discuss current therapeutic strategies for malignant mesothelioma.
  • To highlight the need for collaborative research in MM diagnosis and treatment.

Main Methods:

  • Literature review of malignant mesothelioma developmental pathways.
  • Analysis of current clinical therapies for malignant mesothelioma.
  • Synthesis of research needs for early diagnosis and treatment.

Main Results:

  • Asbestos exposure remains a significant risk factor for MM.
  • MM has a long latency period, extending its threat for decades.
  • Current research focuses on understanding MM development and improving therapies.

Conclusions:

  • Collaborative efforts between researchers and clinicians are essential for combating MM.
  • Further understanding of MM pathogenesis is needed for effective early diagnosis.
  • Advancements in MM therapies are critical for improving patient outcomes.
Keywords:
ASBESTOSINFLAMMATIONMALIGNANT MESOTHELIOMAMESOTHELIUM

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...