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Related Experiment Video

Updated: May 8, 2026

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

Sustained antidepressant response to ketamine.

Onome Victor Atigari¹, David Healy

¹Department of Psychiatry (Hergest Unit), Ysbyty Gwynedd Hospital, Bangor, Wales, UK.

BMJ Case Reports

|August 21, 2013

Summary

This summary is machine-generated.

Ketamine shows sustained antidepressant effects in two bipolar disorder patients, potentially linked to seizure threshold modulation. Further research into ketamine

Related Experiment Videos

Last Updated: May 8, 2026

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Ketamine is an N-methyl-d-aspartate receptor antagonist investigated for antidepressant properties.
Bipolar affective disorder (BAD) is a mood disorder characterized by alternating periods of depression and mania.
Electroconvulsive therapy (ECT) and lithium are established treatments for BAD, influencing seizure threshold.

Observation:

A case series of three patients treated with ketamine for depression was analyzed.
Two patients with BAD experienced sustained antidepressant effects from ketamine.
These responders had a history of positive response to ECT and lithium.

Findings:

Two out of three patients with bipolar affective disorder achieved sustained antidepressant response to ketamine.
These responders did not require maintenance antidepressant therapy.
Ketamine's effect may be related to its influence on seizure threshold, similar to ECT and lithium.

Implications:

Ketamine's impact on seizure threshold warrants further investigation to elucidate its antidepressant mechanism.
This finding suggests a potential therapeutic avenue for treatment-resistant bipolar depression.
Understanding ketamine's full mechanism could optimize its clinical application in mood disorders.