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Related Experiment Video

Updated: May 8, 2026

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Pacing for hypertrophic obstructive cardiomyopathy does it work?

Q Zaidi¹, H Zaky, O Aljassim

¹Cardiology and Cardiothoracic Surgery Center, Dubai Hospital, P.O. Box 21910, Dubai, United Arab Emirates.

Journal of the Saudi Heart Association

|August 21, 2013

Summary

This summary is machine-generated.

A patient with hypertrophic obstructive cardiomyopathy (HOCM) experienced improved symptoms after receiving a dual chamber implantable cardioverter-defibrillator (ICD). Right ventricular apical pacing significantly reduced the left ventricular outflow tract (LVOT) pressure gradient.

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Area of Science:

Cardiology
Cardiac Electrophysiology

Background:

Hypertrophic obstructive cardiomyopathy (HOCM) is a significant cause of sudden cardiac arrest.
Management of HOCM often involves addressing the left ventricular outflow tract (LVOT) gradient.

Purpose of the Study:

To evaluate the efficacy of right ventricular apical pacing in managing symptomatic hypertrophic obstructive cardiomyopathy (HOCM) in a patient who declined septal myomectomy.

Main Methods:

A 69-year-old female patient with HOCM and sudden cardiac arrest received a dual-chamber implantable cardioverter-defibrillator (ICD).
The patient was programmed for right ventricular apical pacing with a short atrioventricular (AV) interval.

Main Results:

Post-pacing, the maximum pressure gradient across the left ventricular outflow tract (LVOT) decreased from 117 mmHg to 21 mmHg.
The patient reported significant improvement in symptoms during a one-year follow-up period.

Conclusions:

Right ventricular apical pacing with a short AV interval can be an effective strategy for reducing the LVOT gradient and improving symptoms in select HOCM patients.
This pacing strategy offers an alternative management option for HOCM patients who are not candidates for or decline surgical intervention.