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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Tenecteplase in prosthetic mitral valve thrombosis.

Masood Ayyub Ghori1, Sherif Bakir, Samer Ellahham

  • 1Cardiac Science Department, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

Journal of the Saudi Heart Association
|August 21, 2013
PubMed
Summary

Prosthetic mitral valve thrombosis can be life-savingly treated with fibrinolytic therapy. This case study shows successful management using tenecteplase, a fibrinolytic agent with low immunogenicity, in a high-risk patient.

Keywords:
Prosthetic valveTenecteplaseThrombosis

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Last Updated: May 8, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Published on: October 16, 2021

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08:12

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Published on: May 26, 2023

Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Prosthetic mitral valve thrombosis is a rare but serious complication.
  • Surgical intervention carries high risks for these patients.
  • Fibrinolytic therapy has shown promise in select cases.

Purpose of the Study:

  • To present a case of prosthetic mitral valve thrombosis.
  • To demonstrate the successful management of this condition with tenecteplase.
  • To highlight tenecteplase as a viable fibrinolytic option.

Main Methods:

  • Clinical data collection.
  • Laboratory parameter assessment.
  • Imaging studies (e.g., echocardiography).
  • Fibrinolytic therapy with tenecteplase administration.

Main Results:

  • Successful resolution of prosthetic mitral valve thrombosis.
  • Patient tolerated tenecteplase therapy well.
  • Absence of significant adverse events or immunogenic reactions.

Conclusions:

  • Tenecteplase is a safe and effective fibrinolytic agent for prosthetic mitral valve thrombosis in high-risk patients.
  • Its low immunogenicity profile makes it a favorable alternative to older agents like streptokinase.
  • This case supports the use of tenecteplase in managing prosthetic valve thrombosis.