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Updated: May 8, 2026

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

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Predicting visual outcomes for macular disease using optical coherence tomography.

Pearse A Keane1, Srinivas R Sadda

  • 1NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, United Kingdom.

Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society
|August 21, 2013
PubMed
Summary

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This summary is machine-generated.

Optical coherence tomography (OCT) has advanced macular disease management. New research focuses on OCT-derived biomarkers beyond retinal thickness to predict visual outcomes in macular diseases.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Macular disease management has evolved with new therapies and optical coherence tomography (OCT).
  • OCT imaging has significantly improved understanding of chorioretinal disease pathophysiology and characteristics.
  • Automated OCT analysis for clinically useful measurements, like retinal thickness, is widely adopted in research and clinical settings.

Purpose of the Study:

  • To review the current state-of-the-art in predicting visual outcomes for macular diseases using OCT.
  • To highlight the importance of visual function assessment and OCT image evaluation fundamentals.
  • To discuss the shift towards identifying novel OCT-derived anatomic biomarkers for predicting visual outcomes.

Main Methods:

  • Review of current literature on optical coherence tomography (OCT) in macular disease.
Keywords:
AMD, age-related macular degenerationAge-related macular degenerationBRVO, branch retinal vein occlusionCME, cystoid macular edemaCNV, choroidal neovascularizationCRVO, central retinal vein occlusionCSC, central serous chorioretinopathyCentral serous chorioretinopathyContrast sensitivityDME, diabetic macular edemaDiabetic macular edemaELM, external limiting membraneERM, epiretinal membraneETDRS, Early Treatment Diabetic Retinopathy StudyGA, geographic atrophyGeographic atrophyIS–OS, inner segment–outer segmentMPS, Macular Photocoagulation StudyMicroperimetryOCT, optical coherence tomographyOptical coherence tomographyPED, pigment epithelium detachmentRPE, retinal pigment epitheliumSurrogate endpointsVisual acuitylogMAR, logarithm of the minimum angle of resolution

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  • Analysis of OCT imaging's role in understanding disease pathophysiology and characteristics.
  • Evaluation of OCT-derived measurements, including retinal thickness, and their predictive value for visual outcomes.

    • Main Results:

    • While OCT-derived retinal thickness measurements are common, they may not reliably predict visual outcomes in many macular diseases.
    • There is a growing focus on identifying new anatomic biomarkers from OCT scans that are predictive of visual outcomes.
    • These novel biomarkers hold potential as surrogate endpoints in clinical trials and prognostic tools.

    Conclusions:

    • Accurate visual function assessment and fundamental OCT image evaluation are crucial.
    • The limitations of retinal thickness measurements necessitate the search for advanced OCT-derived biomarkers.
    • Identifying predictive anatomic biomarkers from OCT is the current frontier for improving clinical trials and patient prognostication in macular diseases.