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Updated: May 8, 2026
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
Glaucoma masqueraders: Diagnosis by spectral domain optical coherence tomography
Jullia A Rosdahl1, Sanjay Asrani
1Duke Eye Center, Duke University, Durham, NC, USA.
Summary
Spectral domain optic coherence tomography (SD-OCT) imaging aids in diagnosing non-glaucomatous optic neuropathies. OCT complements clinical exams, distinguishing these conditions from glaucoma.
Area of Science:
- Ophthalmology
- Medical Imaging
- Neurology
Background:
- Optic nerve and retinal imaging have advanced glaucoma patient care.
- Computerized imaging complements clinical exams but cannot replace them.
- Non-glaucomatous optic neuropathies can mimic glaucoma on imaging.
Purpose of the Study:
- To present spectral domain optic coherence tomography (SD-OCT) findings in non-glaucomatous optic nerve pathologies.
- To illustrate how SD-OCT aids in differentiating these conditions from glaucoma.
Main Methods:
- Analysis of spectral domain optic coherence tomography (SD-OCT) images.
- Case series of five patients with diverse non-glaucomatous optic nerve conditions.
Main Results:
- SD-OCT revealed specific patterns in various optic neuropathies: bilateral temporal thinning (syphilis), superior thinning with arcuate scotoma (optic nerve head drusen), diffuse macular thinning (multiple sclerosis), and sectoral macular thinning (ischemic optic neuropathy, retinal vein occlusion).
- These findings highlight distinct OCT signatures for different pathologies.
Conclusions:
- Spectral domain optic coherence tomography (SD-OCT) is a valuable tool in evaluating optic nerve and retinal health.
- SD-OCT imaging complements the clinical examination for diagnosing both glaucomatous and non-glaucomatous optic neuropathies.
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