Related Experiment Video
Updated: May 8, 2026
09:35
Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
Published on: June 16, 2020
Trace elements in diabetic cardiomyopathy: An electrophysiological overview
Nihal Ozturk1, Yusuf Olgar, Semir Ozdemir
1Nihal Ozturk, Yusuf Olgar, Semir Ozdemir, Department of Biophysics, Akdeniz University Faculty of Medicine, 07070 Antalya, Turkey.
World Journal of Diabetes
|August 21, 2013
Summary
Diabetes Mellitus causes heart dysfunction. Trace elements like vanadium, selenium, zinc, and tungstate show promise in treating diabetic cardiomyopathy by regulating glucose and reducing oxidative stress.
Area of Science:
- Cardiology
- Endocrinology
- Biochemistry
Background:
- Diabetes Mellitus is linked to a distinct cardiomyopathy, independent of vascular disease, causing significant global morbidity and mortality.
- Diabetic cardiomyopathy impairs cardiac performance, specifically early diastolic and late systolic function, likely due to altered regulatory protein activity (e.g., Na+/Ca2+ exchanger, SERCA2a).
- Current therapeutic strategies for diabetic cardiomyopathy are limited.
Purpose of the Study:
- To review the potential therapeutic effects of specific trace elements on diabetic heart complications.
- To explore the mechanisms by which trace elements may counteract diabetes-induced cardiac dysfunction.
Main Methods:
- Literature review focusing on trace elements and their impact on diabetes and cardiac function.
- Discussion of the biological effects of vanadium, selenium, zinc, and tungstate relevant to diabetic cardiomyopathy.
- Analysis of proposed mechanisms including insulin-mimetic activity, antioxidant properties, and regulation of intracellular calcium homeostasis.
Main Results:
- Trace elements are increasingly recognized for their anti-diabetic effects, including glucose homeostasis regulation and oxidative stress reduction.
- These elements can exert insulin-mimetic and antioxidant activities, making them potential candidates for treating diabetes-induced cardiac complications.
- Trace elements modulate organ function as enzyme components and regulate cardiac ion channels and [Ca2+]i homeostasis via antioxidant properties.
Conclusions:
- Vanadium, selenium, zinc, and tungstate warrant further investigation for their therapeutic potential in managing diabetic cardiomyopathy.
- Understanding the specific roles of these trace elements may lead to novel treatment strategies for diabetes-related heart disease.
Related Concept Videos
01:30Dysrhythmias V: Evaluating Dysrhythmias
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
01:30Cardiac Action Potential
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
01:15Dysrhythmias I: Introduction
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
01:19Electrophysiology of Normal Cardiac Rhythm
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
01:29Electrocardiogram
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
01:28Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.