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Related Experiment Video

Updated: May 8, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Polyuria following an overdose.

Angela Collins¹, Nigel A White

¹Intensive Care Unit, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, Dorset BH7 7DW, United Kingdom.

International Journal of Critical Illness and Injury Science

|August 21, 2013

Summary

This summary is machine-generated.

Propofol, a common anesthetic, may cause diabetes insipidus, a condition of excessive thirst and urination. This case report highlights a potential link between propofol and this rare adverse effect.

Keywords:

Diabetes insipidus polyuria propofol

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Last Updated: May 8, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

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Area of Science:

Anesthesiology
Nephrology
Pharmacology

Background:

Diabetes insipidus is characterized by polyuria and polydipsia.
Propofol is a widely used intravenous anesthetic agent.
Adverse effects of propofol are typically mild, but rare complications can occur.

Observation:

A 42-year-old male patient developed diabetes insipidus while admitted to the intensive treatment unit.
The patient was administered propofol for sedation during his ITU stay.
Polyuria resolved upon discontinuation of propofol infusion.

Findings:

The case report suggests a potential causal link between propofol administration and the development of diabetes insipidus.
Animal studies provide a theoretical basis for propofol-induced diabetes insipidus.
This adverse effect of propofol is considered uncommon in human patients.

Implications:

Clinicians should be aware of the potential for propofol to induce diabetes insipidus, although rare.
Further research may be warranted to elucidate the precise mechanism of propofol-induced diabetes insipidus.
Monitoring fluid balance and urine output in patients receiving propofol is advisable.