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Updated: May 8, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine-related symptoms in childhood
1Palm Beach Headache Center, Premiere Research Institute, Palm Beach Neurology, Nova Southeastern University, 4631 N. Congress Avenue, Suite 200, West Palm Beach, FL 33407, USA. PWinner777@aol.com
Insights
Childhood periodic syndromes, precursors to migraine, are now understood as episodic symptoms associated with migraine. This evolution impacts diagnosis, pathophysiology, and management in both children and adults.
Area of Science:
- Neurology
- Pediatric Neurology
- Headache Medicine
Background:
- Childhood periodic syndromes are recognized as precursors to adult migraine.
- Similarities in symptoms and a positive family history of migraine are common in affected children.
- These syndromes can transform into adult migraine with or without aura.
Purpose of the Study:
- To explore the evolution of understanding childhood periodic syndromes.
- To examine the shift in terminology towards episodic symptoms associated with migraine.
- To discuss advancements in diagnostic criteria, pathophysiology, and management.
Main Methods:
- Review of the evolution of diagnostic criteria for headache disorders in children and adults.
- Analysis of the changing terminology from 'periodic symptoms' to 'episodic symptoms'.
- Examination of the International Classification of Headache Disorders' role.
Main Results:
- Understanding has evolved from 'periodic symptoms of childhood' to 'childhood periodic syndromes' and now 'episodic symptoms associated with migraine'.
- The International Classification of Headache Disorders has been key in refining these classifications.
- The new terminology 'episodic symptoms' is broader and not limited to childhood.
Conclusions:
- The classification of episodic symptoms associated with migraine has significantly evolved.
- This evolution impacts the diagnostic criteria, pathophysiology, and management strategies.
- The updated terminology reflects a more inclusive understanding across age groups.
Abstract:
Periodic disorders of childhood often represent precursors of migraine. As we advance our knowledge of migraine and its complicated phenotypic presentation in childhood, we have noted the similarities in overlapping symptoms of children presenting with childhood periodic syndromes. There is often a positive family history of migraine in children that present with periodic syndromes. There is a known transformation of periodic syndromes from childhood into adult migraine with and without aura phenotype. There has been an evolution of our understanding of what was initially referred to as periodic symptoms of childhood and more recently been called childhood periodic syndromes and is now evolving into the terminology of episodic symptoms that are associated with migraine. International classification of headache disorders has been instrumental in the evolution of the classification of headache and children adults. The most recent classification utilizes and replaces the periodic symptom terminology with episodic symptoms that will no longer be limited to just childhood. This article will address the evolution of our understanding of the diagnostic criteria, pathophysiology and management of the episodic syndromes that may be associated with migraine.
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