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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
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Published on: February 22, 2016

Global expression profiling reveals genetic programs underlying the developmental divergence between mouse and human

Lu Xue, Jin-Yang Cai, Jian Ma

  • 1College of Life Sciences, Wuhan University, Wuhan 430072, P,R China. shi@helix.nih.gov.

BMC Genomics
|August 22, 2013
PubMed
Summary

This study presents the first genome-wide gene expression analysis of mouse embryogenesis, revealing conserved and divergent gene regulation programs compared to human development. The findings offer insights into developmental divergence and vertebrate evolution.

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Area of Science:

  • Developmental Biology
  • Comparative Genomics
  • Transcriptomics

Background:

  • Mice are crucial models for human development and disease research.
  • Gene expression analyses have illuminated early embryogenesis but not organogenesis.
  • Mouse and human development diverge significantly during organogenesis.

Purpose of the Study:

  • To conduct a comprehensive gene expression analysis of mouse organogenesis.
  • To compare gene regulation in mouse and human organogenesis.
  • To identify conserved and divergent developmental programs.

Main Methods:

  • Genome-wide gene expression profiling of mouse from egg to organogenesis completion.
  • Functional categorization of genes using Gene Ontology (GO).
  • Comparative transcriptome analysis between mouse and human organogenesis.

Main Results:

  • Distinct temporal gene expression patterns were identified for different functional categories during organogenesis.
  • Conserved and divergent gene regulation programs between mouse and human organogenesis were revealed.
  • Divergent programs likely explain species-specific developmental differences and suggest novel evolutionary strategies.

Conclusions:

  • This is the first genome-wide analysis of entire mouse embryogenesis, providing a transcriptome atlas for comparison with human development.
  • The microarray data can aid in identifying genes related to mouse development and inferring functions of unknown genes.
  • The study provides a foundation for investigating the molecular basis of vertebrate evolution.