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(-)-Arctigenin as a lead compound for anticancer agent
Gui-Rong Chen1, Hong-Fu Li, De-Qiang Dou
1a College of Pharmacy, Liaoning University of Traditional Chinese Medicine , 77 Life One Road, DD Port, Dalian , 116600 , P.R. China.
Abstract:
(-)-Arctigenin, an important active constituent of the traditional Chinese herb Fructus Arctii, was found to exhibit various bioactivities, so it can be used as a good lead compound for further structure modification in order to find a safer and more potent medicine. (-)-Arctigenin derivatives 1-5 of (-)-arctingen were obtained by modifying with ammonolysis at the lactone ring and sulphonylation at C (6') and C (6″) and O-demethylation at CH3O-C (3'), CH3O-C (3″) and CH3O-C (4″), and their anticancer bioactivities were examined.
