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Updated: May 8, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Rubrolide R: a new furanone metabolite from the ascidian Synoicum of the Indian Ocean
Desaraju Smitha1, Muthyala Murali Krishna Kumar, Hechhu Ramana
1a College of Pharmaceutical Sciences, Andhra University , Visakhapatnam , 530003 , Andhra Pradesh India.
Abstract:
A new furanone metabolite of the rubrolide family, rubrolide R as diacetate (1), was isolated from a new species of the ascidian Synoicum, besides the known compounds rubrolide A (as diacetate), cadiolide B and prunolide A. The structure of the new rubrolide was elucidated by a study of spectral data. The crude extract and isolated compounds (prunolide A and cadiolide B) showed antiviral activity against the Japanese encephalitis virus. Prunolide A showed cytotoxic activity against breast cancer cell lines at a concentration of < 1 μM.
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