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Updated: May 8, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

The interferon response to intracellular DNA: why so many receptors?

Leonie Unterholzner1

  • 1Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, DD1 5EH, UK.

Immunobiology
|August 22, 2013
PubMed

Keywords:
AIM2ASCATLDATMAtaxia telangiectasia mutatedBMDCBMDMCARDCTDAIDNA receptorDNA virusDNA-PKcsDNA-dependent activator of IRFsDNA-dependent protein kinase catalytic subunitEBEREBVEpstein–Barr virusEpstein–Barr virus encoded small RNAHFFHMGBHSVHTIFI16IFNIFNγ-inducibe protein 16ILIRF3ISDInnate immunityInterferonMAPKMAVSMDA5MDDCMDMMEFMVAMeiotic recombination 11Modified Vaccinia AnkaraMre11NF-kBPAMPPBMCPMPRRRIG-IRIG-like receptorRLRRNA interferenceRNAiSLESTINGSeVSendai virusTANK-binding kinaseTBK1TLRTREX1Toll-like receptorVACVVSVZ-DNA binding proteinZBP1absent in melanoma 2apoptosis-associated speck-like protein containing a CARDataxia-telangiectasia-like disorder cellsbone marrow-derived dendritic cellsbone marrow-derived macrophagescGAMPcGAScalf thymuscaspase activation and recruitment domaincyclic GMP-AMPcyclic GMP-AMP synthasedouble-strandeddsherpes simplex virusherring testishigh mobility group boxhuman foreskin fibroblastsimmunostimulatory DNAinterferoninterferon regulatory factorinterleukinmelanoma differentiation factor 5mitochondrial antiviral signallingmitogen-activated protein kinasemonocyte-derived dendritic cellsmonocyte-derived macrophagesmouse embryonic fibroblastsnuclear factor kBpathogen-associated molecular patternpattern recognition receptorperipheral blood monocytic cellsperitoneal macrophagesretinoic acid-inducible genesingle-strandedsmall nuclear RNAsnRNAssstimulator of IFN genessystemic lupus erythematosustRNAthree prime repair exonuclease 1transfer RNAvaccinia virusvesicular stomatitis virus

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