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Vasoactive intestinal polypeptide response to ethanol in dogs
T Misawa1, J Aramaki, Y Chijiiwa
1Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
The Tohoku Journal of Experimental Medicine
|May 1, 1990
Summary
Ethanol administration in dogs significantly increased vasoactive intestinal polypeptide (VIP) release. This effect was primarily driven by ethanol's hyperosmolarity, not the ethanol itself.
Area of Science:
- Gastroenterology
- Pharmacology
- Physiology
Background:
- Limited research exists on ethanol's effect on vasoactive intestinal polypeptide (VIP) release.
- The precise mechanism behind ethanol-induced VIP release remains largely unknown.
Purpose of the Study:
- To investigate the mechanism of ethanol-induced VIP release in a canine model.
- To determine if ethanol's osmolarity or the ethanol molecule itself triggers VIP release.
Main Methods:
- Intrajejunal administration of saline, 5% ethanol, 10% ethanol, and isoosmolar hypertonic saline in dogs.
- Measurement of mesenteric immunoreactive VIP (IR-VIP) concentrations.
- Dose-dependent analysis of ethanol's effect and comparison with hypertonic saline.
Main Results:
- Both 5% and 10% ethanol caused significant, dose-dependent increases in mesenteric IR-VIP.
- The increase in IR-VIP induced by 10% ethanol was comparable to that caused by isoosmolar hypertonic saline.
- Mesenteric IR-VIP changes were similar for both 10% ethanol and the isoosmolar hypertonic saline.
Conclusions:
- Ethanol-induced VIP release in dogs is predominantly mediated by its hyperosmolar properties.
- The hyperosmolarity of ethanol, rather than its chemical composition, is the primary driver of VIP release in this context.