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Developmental transitions in C. elegans larval stages.

Ann E Rougvie1, Eric G Moss

  • 1Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA. rougvie@umn.edu

Current Topics in Developmental Biology
|August 22, 2013
PubMed
Summary
This summary is machine-generated.

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The study reveals how microRNAs (miRNAs) in Caenorhabditis elegans control developmental timing. These miRNAs ensure proper cell division and differentiation, coordinating larval stages with molting cycles and environmental cues.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Multicellular development relies on precise molecular timing.
  • Heterochrony, or mistimed development, in Caenorhabditis elegans reveals key regulatory mechanisms.
  • MicroRNAs (miRNAs) are central to the heterochronic pathway.

Purpose of the Study:

  • To provide an overview of the Caenorhabditis elegans heterochronic gene pathway.
  • To explain how this pathway guides developmental transitions.
  • To discuss the role of miRNAs in synchronizing development with molting cycles and environmental cues.

Main Methods:

  • Analysis of heterochronic mutants in Caenorhabditis elegans.
  • Investigation of miRNA-mediated gene regulation.
Keywords:
Developmental timingDiapauseHeterochronicMoltingdaf-12lin-14lin-28lin-4lin-42miRNA

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  • Study of developmental timing during continuous and interrupted larval development.

    • Main Results:

    • Sequentially expressed miRNAs orchestrate larval stage transitions.
    • miRNAs achieve stage-specific gene repression.
    • Developmental timing is synchronized with molting cycles.
    • Environmental cues, like nutrient availability, reversibly halt development via heterochronic genes and miRNAs.

    Conclusions:

    • The heterochronic gene pathway, particularly miRNAs, is crucial for precise developmental timing in C. elegans.
    • This pathway integrates internal developmental programs with external environmental signals.
    • Understanding this pathway offers insights into conserved mechanisms of developmental regulation.