Related Experiment Video
Updated: Mar 1, 2026
11:15
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
8.5K
How I treat CNS lymphomas
James L Rubenstein1, Neel K Gupta, Gabriel N Mannis
1Division of Hematology/Oncology, Helen Diller Comprehensive Cancer Center.
Blood
|August 22, 2013
Summary
Advances in understanding central nervous system (CNS) lymphoma pathogenesis and treatment offer hope for long-term survival. Multidisciplinary care is crucial for diagnosing and managing these complex CNS lymphomas.
Area of Science:
- Neuro-oncology
- Hematology
- Molecular Biology
Background:
- Primary and secondary central nervous system (CNS) lymphoma present complex diagnostic, prognostic, and therapeutic challenges.
- Recent advancements have improved understanding of CNS lymphoma molecular properties and microenvironment.
- Novel treatment strategies have evolved, shifting outlooks from uniformly dismal to potential long-term survival.
Purpose of the Study:
- To provide an overview of current knowledge on CNS lymphoma pathogenesis.
- To highlight promising strategies for diagnosis, staging, and therapeutic management.
- To emphasize the evolving principles of management for CNS lymphoma patients.
Main Methods:
- Review of recent scientific literature on CNS lymphoma.
- Analysis of molecular properties and microenvironment of CNS lymphomas.
- Evaluation of novel treatment strategies and multidisciplinary care approaches.
Main Results:
- Significant progress in elucidating molecular pathogenesis of CNS lymphomas.
- Evolution of novel treatment strategies leading to improved survival rates.
- Recognition of the need for multidisciplinary teams in managing CNS lymphoma.
Conclusions:
- Long-term survival and potential cure are now achievable for a significant fraction of CNS lymphoma patients.
- Effective management requires a multidisciplinary team with diverse expertise.
- Continued research into pathogenesis and treatment strategies is essential for further improving outcomes.
Related Concept Videos
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K