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Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
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Energy expenditure during barbiturate coma.

Christine M Ashcraft1, David C Frankenfield

  • 1Christine M. Ashcraft, Department of Clinical Nutrition, Department of Nursing, Penn State Milton S. Hershey Medical Center, 500 University Dr, Hershey, PA 17033, USA.

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
|August 22, 2013
PubMed
Summary
This summary is machine-generated.

Barbiturate coma moderately reduces resting metabolic rate in critical care patients. This metabolic rate decrease is predictable when considering body temperature and minute ventilation.

Keywords:
artificial respirationcritical illnessenergy metabolismindirect calorimetry comanutritional supportresting energy expenditure

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Area of Science:

  • Critical care medicine
  • Metabolic research
  • Physiology

Background:

  • Barbiturate coma's impact on metabolic rate is not well-understood.
  • Critical care patients require precise metabolic monitoring.
  • Existing research on barbiturate-induced metabolic changes is limited.

Purpose of the Study:

  • To compare the resting metabolic rate (RMR) of patients in barbiturate coma versus general critical care patients.
  • To assess the accuracy of the Penn State prediction equation in these patient groups.

Main Methods:

  • Indirect calorimetry was employed to measure RMR in mechanically ventilated patients.
  • Patients in barbiturate coma were compared to a control group of similar demographics.
  • RMR measurements were compared against predictions from the Penn State equation.

Main Results:

  • Patients in barbiturate coma exhibited a lower RMR than the control group (1859 vs 2037 kcal/d).
  • This difference became statistically insignificant when minute ventilation was included in the analysis (1929 vs 2023 kcal/d).
  • The Penn State equation demonstrated accuracy in 73% of both patient groups.

Conclusions:

  • Resting metabolic rate is moderately reduced in barbiturate coma, disproportionately to body temperature changes.
  • Considering both body temperature and minute ventilation allows for predictable RMR assessment in barbiturate coma.
  • The Penn State equation provides reliable metabolic predictions in critical care settings, including barbiturate coma.