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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: May 8, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Notch signaling in skeletal stem cells.

Shan Chen1, Brendan H Lee, Yangjin Bae

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza Rm R814, Houston, TX, 77030, USA.

Calcified Tissue International
|August 22, 2013
PubMed
Summary

Notch signaling is crucial for skeletal stem cell development, regulating cell fate and maintaining bone and cartilage homeostasis. Dysregulation of this pathway is implicated in bone diseases and cancer, offering therapeutic targets.

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Last Updated: May 8, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
09:19

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

Area of Science:

  • Skeletal biology
  • Developmental biology
  • Cell signaling

Background:

  • Skeletal development involves stem cell proliferation, migration, and commitment, influenced by signaling pathways.
  • Notch signaling is a key pathway regulating cell fate, proliferation, differentiation, and apoptosis in skeletal stem cells.

Purpose of the Study:

  • To review the role of Notch signaling in skeletal development and homeostasis.
  • To explore the implications of Notch signaling dysregulation in bone and cartilage diseases.

Main Methods:

  • Literature review focusing on Notch signaling in skeletal stem cells and related pathologies.
  • Analysis of molecular mechanisms governing cell fate, proliferation, differentiation, and apoptosis.

Main Results:

  • Notch signaling maintains osteochondroprogenitor multipotency and prevents premature osteoblast differentiation.
  • Overactivation of Notch signaling inhibits osteoblast maturation and chondrocyte terminal differentiation.
  • Notch signaling is vital for chondrocyte proliferation and hypertrophy.

Conclusions:

  • Notch signaling plays a critical role in skeletal development, homeostasis, and disease.
  • Understanding Notch signaling mechanisms offers therapeutic strategies for bone and cartilage disorders.
  • Targeting Notch signaling pathways presents opportunities for treating skeletal diseases and tumorigenesis.