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Related Experiment Video

Updated: May 8, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Subpial transection surgery for epilepsy.

Balaji Krishnaiah1, Sridharan Ramaratnam, Lakshmi Narasimhan Ranganathan

  • 1Department of Neurology, Penn State, 30 Hope Drive, Hershey, Pennsylvania, Philadelphia, USA, PA 17033.

The Cochrane Database of Systematic Reviews
|August 22, 2013
PubMed
Summary

This review found no evidence on subpial transection for refractory epilepsy. More randomized controlled trials are needed to determine its benefits and risks for seizure control.

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Area of Science:

  • Neurosurgery
  • Epileptology
  • Clinical Neurology

Background:

  • Refractory epilepsy affects nearly 30% of patients despite antiepileptic drug (AED) regimens.
  • Medically refractory epilepsy is defined as failure to respond to at least two AEDs.
  • Early surgical intervention may improve outcomes in children with uncontrolled epilepsy.

Purpose of the Study:

  • To evaluate the benefits and adverse effects of subpial transection surgery.
  • To assess subpial transection for partial-onset and generalized tonic-clonic seizures.
  • To include both pediatric and adult populations in the analysis.

Main Methods:

  • Searched Cochrane Epilepsy Group Register, CENTRAL, and MEDLINE up to August 2013.
  • Included randomized and quasi-randomized parallel group studies (blinded or non-blinded).

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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

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Last Updated: May 8, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

  • Two independent reviewers screened studies and planned data extraction and verification.

    • Main Results:

    • No relevant studies were identified for inclusion in this review.
    • The search yielded no randomized controlled trials or quasi-randomized studies on subpial transection for epilepsy.

    Conclusions:

    • There is currently insufficient evidence to support or refute subpial transection for medically refractory epilepsy.
    • High-quality randomized controlled trials are essential to guide future clinical practice.
    • Further research is needed to establish the efficacy and safety of this surgical procedure.