[The treatment with hepatoprotectors of patients with chronic liver diseases]

Hepatoprotectors were used in 89 patients with chronic liver diseases from 1 to 6 months. A positive clinico-biochemical and immunological effect, namely, increase of the T-lymphocyte count, normalization of the ratio of immunoregulator cells, reduction of the antibody-dependent cellular toxicity, level of circulating immune complexes, immunoglobulins. Patients with chronic persisting hepatitis showed a stable remission from 6 to 12 months. Despite prolonged treatment, patients with active chronic hepatitis and liver cirrhosis developed exacerbation of the disease that was in 2/3 of patients caused by an increase of deficit of theophyllin-sensitive lymphocytes-suppressors and in 1/3 by K-cell deficit. The necessity is emphasized of interrupted treatment with hepatoprotectors for not less that 2-3 months alternating hepatoprotectors with immunomodulators.