Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone marrow edema in osteoarthritis and bone trauma. Diagnose and treatment.

La Clinica terapeutica·2025
Same author

Physiopathology and pharmacological protection of periprosthetic bone.

La Clinica terapeutica·2025
Same author

An engineered glove to follow finger function in rheumatoid arthritis: an observational prospective study.

Rheumatology international·2023
Same author

Intra-articular clodronate in patients with knee osteoarthritis non-responder to intra-articular hyaluronic acid - a case report series of 9 patients with 8-month follow-up.

La Clinica terapeutica·2023
Same author

Cost-effectiveness and cost-utility of add-on, low-dose prednisolone in patients with rheumatoid arthritis aged 65+: The pragmatic, multicenter, placebo-controlled GLORIA trial.

Seminars in arthritis and rheumatism·2022
Same author

Bone Marrow Edema: pathogenetic features.

La Clinica terapeutica·2022
Same journal

Effects of OsteoStrong vs. dynamic multicomponent exercise on physical function in older women in the BONEMORE randomized controlled trial.

Aging clinical and experimental research·2026
Same journal

Animal-assisted interventions for depression in older adults: an umbrella review with meta-analysis and trial sequential analysis.

Aging clinical and experimental research·2026
Same journal

Needs, resources, and barriers among family caregivers of people with dementia: a qualitative study.

Aging clinical and experimental research·2026
Same journal

Cross-sectional and longitudinal associations of activity diversity with physical function in community-dwelling older adults.

Aging clinical and experimental research·2026
Same journal

Driving the future of geriatric and musculoskeletal medicine-the continuing ascent of ACER.

Aging clinical and experimental research·2026
Same journal

Perceptions, motivations, needs and experiences of geriatricians with regard to research and research consortia.

Aging clinical and experimental research·2026
See all related articles

Related Experiment Videos

Osteoporosis in the elderly.

B Seriolo1, S Paolino, A Casabella

  • 1Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy.

Aging Clinical and Experimental Research
|August 22, 2013
PubMed
Summary
This summary is machine-generated.

Age-related osteoporosis increases bone fragility and fracture risk in older adults. This article reviews current understanding of the pathophysiology behind this common aging condition.

Related Experiment Videos

Area of Science:

  • Gerontology
  • Bone Biology
  • Pathophysiology

Background:

  • Osteoporosis is a prevalent condition in the elderly.
  • It leads to increased bone fragility and fracture susceptibility.
  • Understanding its pathophysiology is crucial for managing age-related bone loss.

Purpose of the Study:

  • To discuss current concepts of age-related osteoporosis.
  • To provide an overview of the pathophysiology of osteoporosis in the elderly.

Main Methods:

  • Review of clinical studies.
  • Analysis of biological studies.
  • Synthesis of current research on age-related osteoporosis.

Main Results:

  • Osteoporosis is primarily an age-related condition.
  • Bone fragility and fracture risk are significantly increased in the elderly.
  • Numerous studies have advanced the understanding of osteoporosis pathophysiology.

Conclusions:

  • Age-related osteoporosis is a major health concern for the elderly population.
  • Continued research is vital for comprehending and mitigating osteoporosis.
  • Current concepts highlight the multifactorial nature of age-related bone fragility.