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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
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Bridging the gap: basic metabolomics methods for natural product chemistry.

Oliver A H Jones1, Helmut M Hügel

  • 1School of Applied Sciences, RMIT University, Melbourne, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|August 22, 2013
PubMed
Summary

Metabolomics offers a new strategy to discover novel therapeutic compounds from natural products. This approach systematically studies complex mixtures, aiding drug discovery without isolating individual ingredients.

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Analytical Chemistry

Background:

  • Natural products are vital sources for drug discovery and development.
  • Declining discovery rates necessitate innovative research strategies.
  • Identifying and isolating novel active compounds from natural sources is increasingly challenging.

Purpose of the Study:

  • To introduce metabolomics as a viable strategy for natural product drug discovery.
  • To outline the fundamental steps for conducting metabolomics experiments.
  • To describe common analytical and statistical methods for data analysis.

Main Methods:

  • Utilizing targeted and global metabolite profiling.
  • Systematic analysis of complex mixtures, such as plant extracts.
  • Application of common analytical and statistical methodologies.

Main Results:

  • Metabolomics enables the study of complex natural product mixtures.
  • This approach bypasses the need for prior isolation of active compounds.
  • Provides a framework for analyzing metabolomic data.

Conclusions:

  • Metabolomics is instrumental in reviving natural product drug discovery.
  • Systematic metabolite profiling accelerates the identification of new therapeutics.
  • This strategy offers a powerful alternative to traditional methods.