Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

Assessment of the Rectum and Anus

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

How to Manage a Patient With Gastric Intestinal Metaplasia: An International Perspective.

Gastroenterology·2020

Same author

The second round of the Dutch colorectal cancer screening program: Impact of an increased fecal immunochemical test cut-off level on yield of screening.

International journal of cancer·2019

Same author

Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression.

The Journal of pathology·2019

Same author

Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group.

Annals of internal medicine·2019

Same author

Personalised screening for colorectal cancer, ready for take-off.

Gut·2019

Same author

Accuracy of endoscopic staging and targeted biopsies for routine gastric intestinal metaplasia and gastric atrophy evaluation study protocol of a prospective, cohort study: the estimate study.

BMJ open·2019

Search research articles

Related Experiment Video

Updated: May 8, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Combining risk factors with faecal immunochemical test outcome for selecting CRC screenees for colonoscopy.

Inge Stegeman¹, Thomas R de Wijkerslooth, Esther M Stoop

¹Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, , Amsterdam, The Netherlands.

|August 22, 2013

Summary

Risk stratification combined with faecal immunochemical testing (FIT) improves colorectal cancer (CRC) screening accuracy. This approach enhances the detection of advanced neoplasia, making CRC screening more effective.

Keywords:

Cancer Epidemiology Cancer Prevention Colorectal Cancer Screening

More Related Videos

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

Related Experiment Videos

Last Updated: May 8, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

Area of Science:

Gastroenterology
Oncology
Preventive Medicine

Background:

Faecal immunochemical testing (FIT) is a common tool for colorectal cancer (CRC) screening.
However, FIT alone has limitations in sensitivity for detecting advanced neoplasia.
Integrating risk factors with FIT may enhance screening efficacy.

Purpose of the Study:

To explore the utility of a risk prediction model in CRC screening.
To improve the sensitivity and diagnostic yield of FIT-based CRC screening.
To evaluate the effectiveness of combining risk stratification with FIT results for colonoscopy allocation.

Main Methods:

Data from the Colonoscopy or Colonography for Screening (CCS) study were analyzed.
A multivariable risk model was developed using questionnaire data (calcium intake, family history, age) and FIT results.
The model's performance (goodness-of-fit, calibration, discrimination) was compared to a FIT-only model.

Main Results:

The risk-based model significantly improved goodness-of-fit (p<0.001) and discrimination (AUC: 0.69 to 0.76, p=0.02) compared to FIT alone.
Calibration of the risk model was good (Hosmer-Lemeshow test, p=0.94).
Prioritizing colonoscopy for the highest-risk individuals, rather than solely based on FIT results, could detect more advanced neoplasia cases.

Conclusions:

Risk-based stratification enhances the accuracy of FIT-based CRC screening.
This combined approach can be effectively used for preselecting individuals for colonoscopy in CRC screening programs.
Improved accuracy and yield can optimize resource allocation in screening.