Related Experiment Video
Updated: May 8, 2026
04:50
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
Published on: January 17, 2025
Radical lymph node dissection and assessment: Impact on gallbladder cancer prognosis
Gui-Jie Liu1, Xue-Hua Li, Yan-Xin Chen
1Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China.
World Journal of Gastroenterology
|August 22, 2013
Summary
Examining more lymph nodes improves gallbladder cancer staging. Retrieving at least six lymph nodes is crucial for accurate prognosis, especially for patients with positive lymph nodes, enhancing disease-specific survival (DSS) prediction.
Area of Science:
- Oncology
- Surgical Pathology
- Cancer Prognostics
Background:
- Gallbladder cancer (GBC) lymph node metastasis patterns are critical for prognosis.
- Optimal categorization of nodal status is essential for accurate staging and treatment planning in GBC.
Purpose of the Study:
- To investigate lymph node metastasis patterns in gallbladder cancer (GBC).
- To evaluate the optimal categorization of nodal status as a prognostic factor for GBC patients.
Main Methods:
- Retrospective analysis of 78 GBC patients undergoing radical resection.
- Detailed recording of demographic, operative, and pathological data.
- Histological examination of retrieved lymph nodes, calculating positive lymph node count (PLNC), total lymph node count (TLNC), and lymph node ratio (LNR).
Main Results:
- Nodal metastasis was present in 47.44% of patients, significantly impacting disease-specific survival (DSS).
- Optimal total lymph node count (TLNC) for accurate staging was determined to be four, with higher TLNC benefiting node-positive patients.
- A cut-off of six nodes for TLNC significantly stratified node-positive patients into distinct survival groups; increasing PLNC and LNR correlated with worse DSS.
Conclusions:
- Both TLNC and LNR are robust predictors of outcome following GBC resection.
- Retrieval and examination of at least six lymph nodes are vital for improving staging accuracy and predicting DSS, particularly in node-positive GBC cases.