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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Gender difference in bone loss and vascular calcification associated with age
Dong-Hyeon Lee1, Ho-Joong Youn, Jeong Eun Yi
1Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicne, Seoul, Korea.
Korean Circulation Journal
|August 22, 2013
Summary
This study found no direct link between bone density and coronary artery calcification but revealed significant gender differences in both conditions. Early bone loss management, particularly in women, is recommended.
Area of Science:
- Gerontology
- Cardiovascular Health
- Bone Metabolism
Background:
- Bone loss and vascular calcification are common age-related conditions.
- Understanding their interplay and gender-specific differences is crucial for public health.
Purpose of the Study:
- To investigate the relationship between coronary artery calcium (CAC) score and bone mineral density (BMD) with age.
- To determine if gender influences the association between CAC score and BMD in healthy individuals.
Main Methods:
- 1727 healthy subjects (mean age 55±10 years) were assessed.
- Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA).
- Coronary artery calcium (CAC) scores were determined by dual-source CT (DSCT).
Main Results:
- Significant gender differences were observed in both BMD and CAC scores.
- Age was independently associated with osteopenia in males.
- Menopause was strongly associated with osteopenia in females.
Conclusions:
- No direct association was found between CAC score and BMD in either gender.
- A notable gender difference exists in CAC scores across normal and osteopenia groups.
- Targeted therapeutic strategies for early bone loss, especially in women, are suggested.
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