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Pyranocoumarins from Zosima absinthifolia (Vent) Link roots
Seyed Mehdi Razavi1, Gholamhasan Imanzadeh, Fatemeh Soghra Jahed
1Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. razavi694@gmail.com
Bioorganicheskaia Khimiia
|August 23, 2013
Summary
Zosima absinthifolia roots yielded two pyranocoumarins, aegelinol and agasyllin. These compounds demonstrated modest to weak antibacterial and antifungal activity in laboratory tests.
Area of Science:
- Phytochemistry
- Pharmacology
- Ethnobotany
Background:
- Zosima absinthifolia (Vent) Link (Apiaceae) is a perennial herb with a history of traditional medicinal use in Iran, Turkey, and Pakistan.
- The plant's indigenous origin and historical applications suggest potential for novel bioactive compound discovery.
Purpose of the Study:
- To isolate and identify bioactive compounds from the roots of Zosima absinthifolia.
- To evaluate the antimicrobial properties of the isolated compounds.
Main Methods:
- Extraction of air-dried, powdered Zosima absinthifolia roots using n-hexane, dichloromethane, and methanol via Soxhlet apparatus.
- Isolation of compounds using vacuum liquid chromatography (VLC) and preparative thin-layer chromatography (P-TLC).
- Antimicrobial activity assessment using the agar dilution method.
Main Results:
- Two pyranocoumarins, aegelinol and agasyllin, were successfully isolated from the dichloromethane extract.
- The purified compounds exhibited modest to weak activity against tested bacteria and fungi.
Conclusions:
- Aegelinol and agasyllin are identified as constituents of Zosima absinthifolia roots.
- The isolated pyranocoumarins possess limited antimicrobial potential.
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