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Related Experiment Video

Updated: May 8, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
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Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

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A Developmental Functional MRI Study of Prefrontal Activation during Performance of a Go-No-Go Task.

B J Casey1, R J Trainor, J L Orendi

  • 1University of Pittsburgh Medical Center.

Journal of Cognitive Neuroscience
|August 23, 2013
PubMed
Summary

Children show greater prefrontal cortex activation volume than adults during response inhibition tasks. This functional magnetic resonance imaging (fMRI) study highlights developmental differences in brain activity patterns for inhibitory control.

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Related Experiment Videos

Last Updated: May 8, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
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Published on: June 20, 2012

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08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Cognitive Neuroscience

Background:

  • Response inhibition is a critical executive function.
  • Prefrontal cortex (PFC) plays a key role in inhibitory control.
  • Developmental changes in PFC activation are not fully understood.

Purpose of the Study:

  • To investigate developmental differences in PFC activation patterns during a Go-No-Go task.
  • To compare functional magnetic resonance imaging (fMRI) activation between children and adults.
  • To explore the relationship between PFC activation and behavioral performance in response inhibition.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) using gradient echo, echo planar imaging.
  • Participants: 9 children and 9 adults.
  • Task: Go-No-Go paradigm assessing response inhibition.

Main Results:

  • No significant difference in the location of PFC activation between children and adults.
  • Significantly greater volume of PFC activation in children compared to adults, particularly in dorsal and lateral regions.
  • Activation observed across dorsolateral and orbitofrontal cortices, correlating with behavioral performance (false alarms).

Conclusions:

  • Developmental differences in PFC activation volume exist during response inhibition.
  • Orbitofrontal and anterior cingulate cortex activity is linked to inhibitory control performance.
  • fMRI is a valuable tool for studying pediatric brain development and function.