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Published on: April 26, 2019
Identification of idiosyncratic Mycobacterium tuberculosis ribosomal protein subunits with implications in
Xiangyu Fan1, Xiemei Tang, Jianlong Yan
1a Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area , School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University , Beibei, Chongqing , 400700 , China .
Abstract:
Ribosome, the protein synthesis machinery essential for all living cells, consists of ribosomal proteins and RNA. Extraribosomal functions have recently been discovered for many ribosomal proteins, acting either as individual regulatory proteins or as a complex with other cell components. However, extraribosomal functions of Mycobacterium tuberculosis ribosomal proteins have not been systematically addressed. To this end, M. tuberculosis ribosomal proteins potentially engaged in extraribosomal functions were curated by data mining from transcriptional profiles of M. tuberculosis exposed to diverse treatments. Six M. tuberculosis ribosomal proteins, namely, S3 (Rv0707, rpsC), L16 (Rv0708, rplP), L29 (Rv0709, rpmC), S17 (Rv0710, rpsQ), S14 (Rv2056c, rpsN2), and L33 (Rv2057c, rpmG1), were found to behave idiosyncratically. The function of these abnormal ribosomal subunits can be further explored. Special emphasis is on their potential value as novel targets for better antibiotics.
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