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Related Experiment Video

Updated: May 8, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

[Antihypertensives: better evenings than mornings].

N P Riksen¹, J Deinum

¹UMC St Radboud, afd. Algemeen Interne Geneeskunde, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde

|August 23, 2013

Summary

Taking blood pressure medication in the evening may improve outcomes for patients with resistant hypertension. This chronotherapy approach shows promise for individuals lacking a nocturnal blood pressure dip, a key indicator of cardiovascular risk.

Area of Science:

Cardiology
Pharmacology
Chronobiology

Background:

Hypertension affects 10-30% of patients, often proving resistant to treatment.
Nocturnal blood pressure is a stronger predictor of cardiovascular events than daytime readings.
A lack of nocturnal blood pressure dip is associated with increased cardiovascular risk.

Purpose of the Study:

To investigate the efficacy of evening administration of antihypertensives.
To explore chronotherapy as a strategy for therapy-resistant hypertension.
To determine if evening dosing improves nocturnal blood pressure control.

Main Methods:

Review of randomized, non-blinded studies on antihypertensive chronotherapy.
Analysis of blood pressure patterns in patients with therapy-resistant hypertension.

Related Experiment Videos

Last Updated: May 8, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Comparison of cardiovascular event rates based on medication timing.

Main Results:

Antihypertensives demonstrate a stronger effect on nocturnal blood pressure when taken in the evening.
Chronotherapy may lower cardiovascular risk in specific patient groups.
Evening dosing is a promising strategy for patients with resistant hypertension and absent nocturnal dip.

Conclusions:

Evening administration of antihypertensives represents a promising chronotherapeutic strategy.
This approach may be particularly beneficial for patients with therapy-resistant hypertension.
Further research is warranted to elucidate the mechanisms and optimize chronotherapy protocols.