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Relation between macrophage infiltrates and peritumoral edema
M Shinonaga1, C C Chang, T Kuwabara
1Department of Neurological Surgery, Yokohama City University School of Medicine, Japan.
Advances in Neurology
|January 1, 1990
Summary
Macrophages and leukotrienes (LTs) may contribute to peritumoral edema in brain tumors. Macrophage infiltration correlated with edema, and leukotriene C4 (LTC4) was detected in cases with edema.
Area of Science:
- Neuro-oncology
- Immunology
- Pathophysiology
Background:
- Peritumoral edema is a significant complication of intracranial neoplasms.
- The precise mechanisms driving peritumoral edema remain unclear.
Purpose of the Study:
- To investigate the involvement of macrophages and leukotrienes (LTs) in the development of brain tumor-associated edema.
- To explore the relationship between macrophage infiltration, LT levels, and the presence of peritumoral edema.
Main Methods:
- Immunohistochemistry using anti-Leu M3 antibody to identify macrophage infiltrates in brain tumor tissues.
- High-performance liquid chromatography (HPLC) to quantify tissue leukotriene C4 (LTC4) and leukotriene D4 (LTD4).
Main Results:
- Macrophage infiltrates were observed in a majority of gliomas, meningiomas, and metastatic brain tumors.
- A strong correlation was found between the extent of macrophage infiltration and the presence of peritumoral edema, as assessed by CT scans.
- LTC4 was frequently detected in tumors with peritumoral edema, whereas it was often absent in tumors without edema or those treated with steroids preoperatively.
Conclusions:
- Macrophages and LTs are implicated as key players in the pathogenesis of peritumoral edema associated with brain tumors.
- Targeting macrophages or LT pathways could offer potential therapeutic strategies for managing brain tumor edema.