Hormonal influences in prostate cancer: an update of a complex subject

Pharmacists who are involved with patients and physicians have a tremendous opportunity to serve in the realm of prostate cancer, and there are numerous compounding opportunities. For example, compounded testosterone gels can help keep testosterone levels in the mid to upper range with proper dosing and patient counseling. Also, estradiol levels can be held in check or lowered by compounding aromatase-inhibitors such as anastrazole or letrazole into the lower doses that men require, rather than their more potent versions for female patients. Nutraceuticals such as omega-3 fatty acids, vitamin D, zinc, and selenium all play an important role in prostate health, as these agents have 5a-reductase inhibiting and anti-inflammatory properties. More than anything else, we see that the pathophysiology of prostate cancer, although quite complex, is being explored at an amazing rate. The author believes that hormonal balance is critical, and that it is largely hormonal imbalance that is involved in prostate disease. In that regard, the author concludes that the levels of testosterone, estradiol, and drotestosterone, experienced at a more youthful age are vital if we are to improve prostate health.