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Related Experiment Video

Updated: May 8, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

Electroconvulsive therapy and Klinefelter syndrome.

Qiang Wei¹, Xinhui Xie, Yang Chen

¹Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Anhui Province, China.

The Journal of ECT

|August 23, 2013

Summary

Klinefelter syndrome (47,XXY) increases psychosis risk. Modified electroconvulsive therapy effectively treated a patient with Klinefelter syndrome and refractory psychiatric symptoms, showing remarkable improvement.

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Area of Science:

Genetics
Neuroscience
Psychiatry

Background:

Klinefelter syndrome, a sex chromosome aneuploidy (most common karyotype 47,XXY), is linked to an elevated risk of psychiatric disorders.
Psychosis is a recognized comorbidity, necessitating effective treatment strategies.

Observation:

A case study involving a patient diagnosed with Klinefelter syndrome presented with severe psychiatric symptoms.
The patient's condition was refractory to standard pharmacological treatments, including clozapine and sodium valproate.

Findings:

Modified electroconvulsive therapy (mECT) was administered over 11 sessions.
The patient exhibited a remarkable improvement in psychiatric symptoms following the course of mECT.

Implications:

This case highlights the potential efficacy of mECT in managing treatment-resistant psychosis associated with Klinefelter syndrome.
Further research into the neurobiological underpinnings and therapeutic applications of mECT in sex chromosome disorders is warranted.