Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of Source Parameters on the Polarization Properties of Beams for Practical Free-Space Quantum Key Distribution.

Entropy (Basel, Switzerland)·2021
Same author

Defining the T<sub>H</sub>17 cell lineage.

Nature reviews. Immunology·2021
Same author

Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity.

Science advances·2021
Same author

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Cell reports·2021
Same author

Oestradiol promotes the intrahepatic bile duct development of C57BL/6CrSlc mice during embryonic period via Notch signalling pathway.

Journal of cellular and molecular medicine·2021
Same author

IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene.

PLoS genetics·2021

Related Experiment Video

Updated: May 8, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E virus genotype 4, Nanjing, China, 2001-2011.

Xing Dai, Chen Dong, Zhenxian Zhou

    Emerging Infectious Diseases
    |August 23, 2013
    PubMed
    Summary

    Hepatitis E virus (HEV) genotype 4, predominantly subgenotype 4a, was detected in Nanjing, China between 2001-2011. The virus population grew significantly starting in the 1980s before stabilizing around 2003.

    Keywords:
    ChinaNanjingacute infectionevolutiongenotype 4hepatitis Ehepatitis E virusviruses

    More Related Videos

    Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
    04:11

    Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

    Published on: December 15, 2023

    Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
    09:02

    Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

    Published on: June 5, 2020

    Related Experiment Videos

    Last Updated: May 8, 2026

    A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
    10:28

    A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

    Published on: June 26, 2020

    Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
    04:11

    Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

    Published on: December 15, 2023

    Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
    09:02

    Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

    Published on: June 5, 2020

    Area of Science:

    • * Virology and epidemiology of infectious diseases.
    • * Public health surveillance of viral infections.

    Background:

    • * Hepatitis E virus (HEV) is a significant cause of acute hepatitis globally.
    • * Genotype 4 is a prevalent HEV genotype in Asia, with various subgenotypes circulating.
    • * Understanding viral population dynamics is crucial for public health interventions.

    Purpose of the Study:

    • * To characterize the HEV genotypes and subgenotypes circulating in Nanjing, China.
    • * To investigate the temporal population dynamics of HEV in the region.
    • * To provide insights into HEV transmission patterns.

    Main Methods:

    • * Retrospective analysis of HEV RNA in blood samples from patients in Nanjing.
    • * Genotyping and subgenotyping of detected HEV strains.
    • * Phylogenetic analysis to infer population dynamics and evolutionary history.

    Main Results:

    • * HEV was detected in patients during the 2001-2011 period.
    • * All identified HEV strains belonged to genotype 4, with subgenotype 4a being the most common.
    • * The effective population size of HEV in Nanjing showed a marked increase from approximately 1980 until 2003, after which it stabilized.

    Conclusions:

    • * HEV genotype 4, specifically subgenotype 4a, was the dominant circulating strain in Nanjing during the study period.
    • * A significant expansion of the HEV effective population occurred from the 1980s to the early 2000s.
    • * These findings highlight the importance of ongoing HEV surveillance and control measures in the region.