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Sulfonylurea receptor 1 expression in human cerebral infarcts
Rupal I Mehta1, Svetlana Ivanova, Cigdem Tosun
1Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201-1595, USA.
Journal of Neuropathology and Experimental Neurology
|August 23, 2013
Summary
Sulfonylurea receptor 1 (Sur1) is upregulated in human stroke brains, with distinct cell-specific temporal patterns. This finding suggests Sur1 may be a promising therapeutic target for acute cerebral infarction.
Area of Science:
- Neuroscience
- Molecular Biology
- Pathology
Background:
- Sulfonylurea receptor 1 (Sur1) is implicated in edema and cell death in animal stroke models.
- Sur1 expression in human stroke brains remains largely uncharacterized.
Purpose of the Study:
- To systematically evaluate Sur1 expression in human postmortem brain specimens following focal and lacunar infarcts.
- To investigate the temporal dynamics of Sur1 expression in different cell types within the infarct area.
Main Methods:
- Immunohistochemistry was used to detect Sur1 immunoreactivity in postmortem brain tissues from patients with focal infarcts, lacunar infarcts, and healthy controls.
- In situ hybridization was employed to confirm Abcc8 mRNA upregulation.
Main Results:
- Elevated Sur1 immunoreactivity was observed in all focal infarct cases.
- Distinct temporal patterns of Sur1 expression were identified: early neuronal/endothelial, progressive astrocytic/microglial, and sustained neutrophilic.
- Sur1 expression was less prominent and more sporadic in lacunar infarcts compared to nonlacunar infarcts.
Conclusions:
- Sur1 is upregulated in human cerebral infarcts with specific temporal and cellular profiles.
- The findings support Sur1 as a potential therapeutic target for acute cerebral infarction.
