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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: May 8, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Non-coding RNAs and cancer.

Federica Calore¹, Francesca Lovat, Michela Garofalo

¹Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. federica.calore@osumc.edu

International Journal of Molecular Sciences

|August 23, 2013

Summary

This summary is machine-generated.

Non-coding RNAs (ncRNAs) are crucial in cancer. Their expression profiles aid in diagnosis, prognosis, and treatment response, highlighting their therapeutic potential.

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Published on: December 13, 2018

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Last Updated: May 8, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

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Published on: December 13, 2018

Area of Science:

Molecular Biology
Genomics
Oncology

Background:

Non-coding RNAs (ncRNAs) have emerged as critical regulators in biological processes.
Expression profiling of ncRNAs in human tumors reveals signatures linked to cancer characteristics.
MicroRNAs (miRNAs) and other ncRNAs play significant roles in cancer development and progression.

Purpose of the Study:

To review recent advancements in understanding the biological functions of human ncRNAs in cancer.
To discuss the mechanisms governing ncRNA expression in cancerous cells.
To explore the therapeutic potential of ncRNAs for cancer treatment.

Main Methods:

Literature review of recent studies on ncRNAs in human cancer.
Analysis of expression profiling data for miRNAs and other ncRNAs in tumors.
Synthesis of information on ncRNA functions, regulation, and clinical applications.

Main Results:

ncRNAs, including miRNAs, are key players in cancer diagnosis, staging, progression, and prognosis.
Specific ncRNA expression patterns serve as biomarkers for various cancer types.
ncRNAs influence multiple cellular pathways relevant to tumorigenesis and treatment response.

Conclusions:

ncRNAs represent a significant area of advancement in molecular biology and cancer research.
Targeting ncRNAs offers promising therapeutic strategies for cancer intervention.
Further research into ncRNA mechanisms and functions will enhance their clinical utility.