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Related Experiment Videos

The bleeding time response to aspirin. Identifying the hyperresponder.

L D Fiore1, M T Brophy, A Lopez

  • 1Boston Veterans Administration Medical Center, Massachusetts 02130.

American Journal of Clinical Pathology
|September 1, 1990
PubMed
Summary

Aspirin (ASA) temporarily prolongs bleeding time, with effects peaking at 12 hours. A bleeding time increase over 5.9 minutes after a 325 mg dose identifies aspirin hyper-responders.

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Area of Science:

  • Pharmacology
  • Hematology
  • Clinical Medicine

Background:

  • Aspirin (ASA) is widely used for its antiplatelet effects.
  • Individual responses to aspirin can vary, impacting bleeding risk.

Purpose of the Study:

  • To investigate the dose-dependent effects of aspirin on template bleeding time.
  • To identify a reliable method for distinguishing aspirin hyper-responders.

Main Methods:

  • Template bleeding time was measured in subjects at various intervals after single doses of aspirin (74 mg, 325 mg, 3,900 mg).
  • A prospective, randomized, double-blinded study assessed bleeding time 7 hours after placebo or 325 mg aspirin in 39 additional subjects.
  • Hyper-responders (HRs) were defined as those with bleeding time prolongation > 5.9 minutes.

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Main Results:

  • Aspirin significantly increased bleeding time, with maximal prolongation observed at 4 and 12 hours post-ingestion, regardless of dose.
  • In the double-blinded study, 14% of subjects were identified as hyper-responders.
  • Baseline bleeding time and platelet aggregation tests did not differentiate hyper-responders from normal responders.

Conclusions:

  • A single 325 mg dose of aspirin prolongs bleeding time in a predictable manner.
  • A bleeding time prolongation exceeding 5.9 minutes, seven hours after a 325 mg aspirin dose, can identify hyper-responders in individuals with normal baseline bleeding times.