Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated proteogenomic profiling reveals coordinated differential expression signatures during neuroinflammation.

Acta neuropathologica communications·2026
Same author

Agent-based modeling of erosion and sloughing during growth of Pseudomonas aeruginosa biofilms.

NPJ biofilms and microbiomes·2026
Same author

Opening the black box of neural variability: From noise to mechanisms.

Neuroscience and biobehavioral reviews·2026
Same author

Unstable slow oscillations couple with epileptogenic fast-rhythm bistability in sleep-related epilepsy: A stereoelectroencephalographic study.

Epilepsia·2026
Same author

A lineage-based model of scalable positional information in vertebrate brain development.

Neuron·2026
Same author

High density EEG and deep learning outcome prediction on the first day of coma after cardiac arrest.

NeuroImage·2025

Related Experiment Video

Updated: May 8, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

Simulating cortical development as a self constructing process: a novel multi-scale approach combining molecular and

Frederic Zubler1, Andreas Hauri, Sabina Pfister

  • 1Institute of Neuroinformatics, University of Zürich/Swiss Federal Institute of Technology Zürich, Switzerland. fred@ini.phys.ethz.ch

Plos Computational Biology
|August 23, 2013
PubMed
Summary
This summary is machine-generated.

This study models neocortical development, showing how a common genome guides individual cell behaviors to create complex brain architecture. It demonstrates self-construction principles in embryological development.

More Related Videos

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
06:17

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

Published on: October 23, 2015

Related Experiment Videos

Last Updated: May 8, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
06:17

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

Published on: October 23, 2015

Area of Science:

  • Developmental biology
  • Computational neuroscience
  • Genomics

Background:

  • Existing embryological development models primarily focus on intracellular processes.
  • The relationship between subcellular events and collective cellular organization is not well understood.
  • Neocortical development involves complex cellular organization and differentiation.

Purpose of the Study:

  • To model neocortical development by focusing on collective cellular behavior.
  • To explore how individual cell behaviors contribute to overall brain architecture.
  • To demonstrate principles of self-construction in embryological development.

Main Methods:

  • Developed a computational model simulating neocortical expansion from progenitor cells.
  • Utilized a formal language analogous to genomic instructions to steer development.
  • Incorporated physically realistic three-dimensional environments and cell behaviors.
  • Simulated cell differentiation, migration, and the extension of dendrites and axons.

Main Results:

  • Successfully modeled the formation of a laminated cortex with layer-specific projections.
  • Replicated experimentally determined branching patterns of neuronal cell types from the cat visual cortex.
  • Demonstrated how a common genome can drive collective developmental sequences.
  • Showcased principles of self-construction in cortical development.

Conclusions:

  • The study provides the first comprehensive demonstration of self-construction in cortical development.
  • The model highlights the role of collective cell behavior in generating complex biological structures.
  • The findings offer testable predictions regarding cell migration and branching mechanisms.