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Renal dysfunction in burns: a review

A E Ibrahim1, K A Sarhane, S P Fagan

  • 1Department of Surgery, Division of Burns, Massachusetts General Hospital, Harvard Medical School; Boston, Massachusetts, USA.

Annals of Burns and Fire Disasters
|August 23, 2013
PubMed

Insights

Acute kidney injury (AKI) is a rare but serious complication in burn patients. Early diagnosis and prevention are crucial due to undefined treatment guidelines and high mortality rates.

Area of Science:

  • Burn injury research
  • Nephrology
  • Critical care medicine

Background:

  • Acute kidney injury (AKI) is a significant, though infrequent, complication of severe burn injuries.
  • AKI in burn patients stems from complex cellular and neuro-humoral dysregulations.
  • Current treatment guidelines for burn-related AKI are not well-established.

Purpose of the Study:

  • To elucidate the physiological changes in burn patients that predispose them to AKI.
  • To outline strategies for the early detection of AKI in this population.
  • To review current and potential treatment approaches for burn-induced AKI.

Main Methods:

  • Literature review focusing on burn patient physiology and AKI.
  • Analysis of cellular and neuro-humoral factors implicated in burn-related AKI.
  • Synthesis of diagnostic criteria and therapeutic interventions for AKI in burn survivors.

Main Results:

  • Burn injuries trigger multifaceted systemic responses contributing to renal dysfunction.
  • Early identification of AKI necessitates a thorough understanding of homeostatic alterations.
  • Effective management hinges on prompt diagnosis and tailored interventions.

Conclusions:

  • Understanding burn pathophysiology is essential for preventing AKI.
  • Early diagnostic markers and strategies are paramount for improving outcomes.
  • A comprehensive approach integrating prevention, early detection, and updated treatment is vital for managing AKI in burn patients.
Keywords:
classification of kidney injurydialysis in burnskidney dysfunction in burnsrenal failure in burnstreatment of renal failure

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