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Related Experiment Videos

Pacing during reperfusion elevates regional myocardial oxygen consumption.

J Kedem1, B A Acad, H R Weiss

  • 1Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5565.

The American Journal of Physiology
|September 1, 1990
PubMed
Summary

Reperfused heart muscle has significant untapped oxygen reserves. Studies show that even after heart attack reperfusion, the myocardium can increase blood flow and oxygen use when demand rises.

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Area of Science:

  • Cardiovascular Physiology
  • Myocardial Metabolism
  • Ischemia-Reperfusion Injury

Background:

  • Coronary artery occlusion leads to reduced blood flow and increased oxygen extraction in reperfused myocardium.
  • This suggests limited flow and oxygen consumption reserves in the reperfused heart muscle, even hours after reperfusion.

Purpose of the Study:

  • To investigate the capacity of reperfused myocardium to increase regional blood flow and oxygen consumption.
  • To assess these reserves under conditions of sustained increased oxygen demand induced by atrial pacing.

Main Methods:

  • Two groups of dogs underwent 2 hours of coronary artery occlusion followed by 4 hours of reperfusion.
  • One group was subjected to atrial pacing (40% heart rate increase) during reperfusion.
  • Regional myocardial oxygen saturation, blood flow (using radiolabeled microspheres), and consumption were measured.

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Main Results:

  • Paced reperfused myocardium exhibited significantly higher regional blood flow compared to unpaced controls.
  • Oxygen extraction in reperfused subendocardium was elevated in controls but not significantly affected by pacing.
  • Myocardial oxygen consumption was significantly increased in all regions of the paced heart.

Conclusions:

  • Reperfused myocardium demonstrates substantial unutilized oxygen supply and consumption reserves.
  • The heart muscle can augment blood flow and oxygen utilization in response to increased demand post-reperfusion.